Search results for "Cytochrome p450 enzyme"

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Multifaceted contributions of epidermal langerhans cells to cutaneous carcinogenesis.

2015

Cutaneous squamous cell carcinoma (SCC) is the most prevalent invasive malignancy with metastatic potential. The epidermis is exposed to a variety of environmental DNA-damaging chemicals, principal among which are polyaromatic hydrocarbons (PAH) ubiquitous in the environment, tobacco smoke, and broiled meats. Langerhans cells (LC) comprise a network of dendritic cells situated adjacent to basal, suprabasal, and follicular infundibular keratinocytes that when mutated can give rise to SCC, and LC-intact mice are markedly more susceptible than LC-deficient mice to chemical carcinogenesis provoked by initiation with the model PAH, 7,12-dimethylbenz[a]anthracene (DMBA). LC rapidly internalize an…

Skin Neoplasmsintegumentary systemCarcinogenesisCYP1B1Cell BiologyDermatologyMetabolismBiologymedicine.disease_causeBiochemistryArticlebody regionsPolyaromatic hydrocarbonCytochrome p450 enzymeBiochemistryLangerhans CellsmedicineCancer researchCarcinoma Squamous CellAnimalsCarcinogenesisMolecular BiologyMutagensThe Journal of investigative dermatology

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